Publications
2018
Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7
(MKK7) γ Isoform are Regulated through Binding to the Phosphatase Calcineurin (2018).
Emily S. Gibson, Kevin M. Woolfrey, Huiming Li, Patrick G. Hogan, Raphael A. Nemenoff,
Lynn E. Heasley and Mark L. Dell’Acqua. Molecular Pharmacology January 1, 2019, 95 (1) 20-32;
DOI: https://doi.org/10.1124/mol.118.113159
Preselection of Lung Cancer Cases Using FGFR1 mRNA and Gene Copy Number for Treatment With Ponatinib (2018).
Terry L. Ng, Hui Yu, Derek E. Smith, Theresa A. Boyle, Emily R. York, Scott Leedy, Dexiang Gao,
Dara L. Aisner, Adrie Van Bokhoven, Lynn E. Heasley, Fred R. Hirsch, D. Ross Camidge.
Clin Lung Cancer. 2018 Sep 7. pii: S1525-7304(18)30234-1. doi: 10.1016/j.cllc.2018.09.001.
A miRNA Panel Predicts Sensitivity of FGFR Inhibitor in Lung Cancer Cell Lines (2018). Shengxiang Ren,
Christopher J. Rivard, Hui Yu, Carlo Genova, Leslie Rozenboom, Dexiang Gao, Trista K. Hinz, Brad A. Rikke,
Murry W. Wynes, Charles Caldwell, Francesco Agustoni, Kenichi suda, Tao Jiang, Caicun Zhou, Lynn E. Heasley,
Fred R. Hirsch. Clin Lung Cancer. 2018 Sep;19(5):450-456. doi: 10.1016/j.cllc.2018.06.004.
Linking tyrosine kinase inhibitor-mediated inflammation with normal
epithelial cell homeostasis and tumor therapeutic responses (2018). Gurule NJ and Heasley LE.
Cancer Drug Res. In press.
Altered cell-cycle control, inflammation and adhesion in high-risk persistent bronchial dysplasia. (2018)
Merrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD,
Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, O'Shea C, Coldren C,
Orlicky DJ, Lu X, Baron AE, Hickey G, Kennedy TC, Powell R, Heasley L, Bunn PA, Geraci M, Nemenoff RA.
Cancer Res. In press. PMID: 29997230
Inhibition of EphB4-Ephrin-B2 Signaling Enhances Response to Cetuximab-Radiation Therapy in Head and Neck Cancers.
(2018). Bhatia S, Sharma J, Bukkapatnam S, Oweida A, Lennon S, Phan A, Milner D, Uyanga N, Jimeno A, Raben D,
Somerset H, Heasley L, Karam SD. Clin Cancer Res. In press. PMID: 29848571
Mechanisms of rapid cancer cell reprogramming initiated by targeted receptor tyrosine kinase
inhibitors and inherent therapeutic vulnerabilities (2018). Kleczko EK, Heasley LE.
Mol Cancer. 17(1):60. PMID: 29458371 PMCID: PMC5817864
ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer (2018).
Pilling AB, Kim J, Estrada-Bernal A, Zhou Q, Le AT, Singleton KR, Heasley LE, Tan AC, DeGregori J, Doebele RC.
Oncotarget. 9(10):8823-8835. PMID: 29507657 PMCID: PMC5823650
2017
The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade (2017).
Li HY, McSharry M, Bullock B, Nguyen TT, Kwak J, Poczobutt JM, Sippel TR, Heasley LE, Weiser-Evans MC,
Clambey ET, Nemenoff RA. Cancer Immunol Res. 5(9):767-777. PMID: 28819064 PMCID: PMC5787226
Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and
neck squamous cell carcinoma (2017). Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C,
Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD.
Oncoimmunology. 6(10):e1356153. PMID: 29123967 PMCID: PMC5665079
Therapy-induced E-cadherin downregulation alters expression of programmed death ligand-1 in lung cancer cells (2017).
Kenichi Suda, Leslie Rozeboom, Christopher J. Rivard, Hui Yu, Kim Ellison, Mary Ann C. Melnick, Trista K. Hinz,
Daniel Chan, Lynn E. Heasley, Katerina Politi, Tetsuya Mitsudomi, Fred R. Hirsch.
Lung Cancer. 2017 Jul;109:1-8. doi: 10.1016/j.lungcan.2017.04.010.
Co-dependency of PKCδ and K-Ras: inverse association with cytotoxic drug sensitivity in
KRAS mutant lung cancer (2017). Ohm AM, Tan AC, Heasley LE, Reyland ME.
Oncogene. 36(30):4370-4378. PMID: 28368426 PMCID: PMC5532068
EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases (2017).
Vaishnavi A, Schubert L, Rix U, Marek LA, Le AT, Keysar SB, Glogowska MJ, Smith MA, Kako S,
Sumi NJ, Davies KD, Ware KE, Varella-Garcia M, Haura EB, Jimeno A, Heasley LE, Aisner DL, Doebele RC.
Cancer Res. 77(13):3551-3563. PMID: 28428274 PMCID: PMC5516930
Analysis of Drug Resistance Using Kinome-Wide Functional Screens (2017).
Singleton KR, Earley KT, Heasley LE.
Methods in Molec Biol (Clifton, N.J.). 1636:163-177. PMID: 28730479
2016
2015
Identifying kinase dependency in cancer cells by integrating high-throughput drug screening
and kinase inhibition data (2015). Ryall KA, Shin J, Yoo M, Hinz TK, Kim J, Kang J, Heasley LE, Tan AC.
Bioinformatics. 2015; 31(23):3799-806.PMID: 26206305 PMCID: PMC4675831
Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for
Treatment of Lung Cancer and HNSCC (2015). Singleton KR, Hinz TK, Kleczko EK, Marek LA, Kwak J,
Harp T, Kim J, Tan AC, Heasley LE. Cancer Res. 2015; 75(20):4398-406. NIHMSID: NIHMS718410
FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers (2015).
Göke F, Franzen A, Hinz TK, Marek LA, Yoon P, Sharma R, Bode M, von Maessenhausen A, Lankat-Buttgereit B,
Göke A, Golletz C, Kirsten R, Boehm D, Vogel W, Kleczko EK, Eagles JR, Hirsch FR, Van Bremen T, Bootz F,
Schroeck A, Kim J, Tan AC, Jimeno A, Heasley LE, Perner S.
Clin Can Res 21(19):4356-64. PMID: 26015511 PMCID: PMC4592392
2014
Expression and role of the embryonic protein SOX2 in head and neck squamous cell carcinoma (2014). Andreas Schröck,
Maike Bode, Friederike Johanna Maria Göke, Petra Marion Bareiss, Rebekka Schairer, Hui Wang, Wilko Weichert,
Alina Franzen, Robert Kirsten, Tobias van Bremen, Angela Queisser, Glen Kristiansen, Lynn Heasley, Friedrich Bootz,
Claudia Lengerke, Sven Perner. Carcinogenesis, Volume 35, Issue 7, 1 July 2014, Pages 1636–1642,
https://doi.org/10.1093/carcin/bgu094
Nonamplified FGFR1 Is a Growth Driver in Malignant Pleural Mesothelioma (2014). Lindsay A. Marek, Trista K. Hinz,
Anne von Mässenhausen, Kyle A. Olszewski, Emily K. Kleczko, Diana Boehm, Mary C. Weiser-Evans, Raphael A. Nemenoff,
Hans Hoffmann, Arne Warth, Joseph M. Gozgit, Sven Perner and Lynn E. Heasley. Mol Cancer Res October 1 2014 (12)
(10) 1460-1469; DOI: 10.1158/1541-7786.MCR-14-0038
2013
2012
2011
2010 and earlier
Rapidly Acquired Resistance to EGFR Tyrosine Kinase
Inhibitors in NSCLC Cell Lines through De-Repression of
FGFR2 and FGFR3 Expression (2010). Kathryn E. Ware , Marianne E. Marshall, Lydia R. Heasley, Lindsay Marek,
Trista K. Hinz, Paula Hercule, Barbara A. Helfrich, Robert C. Doebele, Lynn E. Heasley. PLoS ONE 5(11): e14117.
https://doi.org/10.1371/journal.pone.0014117
Tyrosine kinase growth factor receptors but not seven‐membrane–spanning receptors or phorbol esters
activate mitogen‐activated protein kinase in rat hepatocytes (1995). Ginès, P. , Li, X. , Zamarripa,
J. L., Brown, S. E., Wieder, E. D., Nakamura, T. , Guzelian, P. S., Schrier, R. W., Heasley, L. E.
and Nemenoff, R. A. Hepatology, 22: 1296-1303. doi:10.1002/hep.1840220440